Journal
FEBS LETTERS
Volume 583, Issue 2, Pages 470-474Publisher
WILEY
DOI: 10.1016/j.febslet.2008.12.053
Keywords
Acetyl-L-carnitine; AMP-activated protein kinase; Insulin resistance; Tumor necrosis factor-alpha
Funding
- Ministry of Science and Technology of the People's Republic of China [2006BAD27B01]
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In this study, we demonstrated effects of acetyl-L-carnitine (ALC) on insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in rat L6 cells. TNF-alpha downregulated insulin-stimulated glucose uptake and increased Serine 307 phosphorylation of insulin receptor substrate-1 (IRS-1). However, the treatment of ALC improved insulin-stimulated glucose uptake via AMP-activated protein kinase (AMPK) activation in a dose-dependent manner. Together, our data suggest that ALC inhibits TNF-alpha-induced insulin resistance through AMPK pathway in skeletal muscle cells. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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