Journal
FEBS LETTERS
Volume 582, Issue 15, Pages 2257-2262Publisher
WILEY
DOI: 10.1016/j.febslet.2008.05.021
Keywords
TRPV1; vanilloid receptor 1; VR1; obesity; capsaicin; adipocyte; CGRP
Funding
- NIAID NIH HHS [R01 AI054450-04, AI 54450, R01 AI054450] Funding Source: Medline
- NINDS NIH HHS [NS 055023, R01 NS055023, R01 NS055023-01A2] Funding Source: Medline
Ask authors/readers for more resources
We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild-type and TRPV1-null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1-null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild-type and TRPV1 -null mice were similar to 51 and 34 g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1-null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3-L1 preadipocytes expressed functional calcitonin gene-related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1-sensitive sensory nerves may regulate energy and fat metabolism. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available