Journal
FEBS LETTERS
Volume 583, Issue 1, Pages 128-134Publisher
WILEY
DOI: 10.1016/j.febslet.2008.11.036
Keywords
Smooth muscle cell; Proliferation; S100; Human; Porphyromonas gingivalis
Funding
- Japan Society for the Promotion of Science [19209063, 18592028, 18791347, 18689050]
- Center of Excellence program entitled Origination of Frontier BioDentistry held at Osaka University Graduate School of Dentistry
- Grants-in-Aid for Scientific Research [18791347, 18689050, 18592028] Funding Source: KAKEN
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We investigated the effect of a periodontal pathogen, Porphyromonas gingivalis, on human aortic smooth muscle cell (hAOSMC) proliferation as mechanisms of atherosclerosis. Cultured hAOSMCs exposed to the supernatant of plasma incubated with P. gingivalis showed a marked transformation from a contractile to proliferative phenotype, resulting in enhancement of cell growth. DNA micro-array analysis revealed a P. gingivalis-dependent upregulation of S100A9 in hAOSMCs. Small interference-RNA for S100A9 dramatically attenuated the effect of P. gingivalis on transformation and proliferation of hAOSMCs. Our data suggested that upregulation of S100A9 mediated by P. gingivalis is an important event in the development of aortic intimal hyperplasia. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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