Journal
FEBS LETTERS
Volume 582, Issue 20, Pages 3097-3102Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.08.005
Keywords
angiogenesis; spheroid; RPE; endothelial; CNV; rapamycin
Funding
- the Forschungskommission Freiburg
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Anti-VEGF treatment has become accepted first-line treatment for choroidal neovascularisation (CNV) in age-related macular degeneration. However, VEGF-inhibition does not always lead to sustained CNV-reduction. In this study, the effect of rapamycin was superior to VEGF-inhibition in a co-culture assay of endothelial cells (ECs) and retinal pigment epithelium (RPE). Rapamycin reduced EC sprouting in groups that did not respond to anti-VEGF treatment. Rapamycin did not induce EC apoptosis, but reduced both VEGF-production in RPE and the responsiveness of ECs to stimulation. Rapamycin might therefore be a therapeutic option for CNV patients that do not respond sufficiently to the established anti-VEGF treatments. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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