Journal
FEBS LETTERS
Volume 582, Issue 30, Pages 4137-4142Publisher
WILEY
DOI: 10.1016/j.febslet.2008.11.014
Keywords
Microrna; Heat-shock; Myocardial infarction; Apoptosis
Funding
- NIH [HL51045, HL59469, HL79424, HL093685]
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We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat-shock (HS) showed a significant increase of miRNA-1, miRNA-21 and miRNA-24 in the heart. miRNAs isolated from HS mice and injected into non-HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro-apoptotic genes and increase in anti-apoptotic genes. Chemically synthesized miRNA-21 also reduced infarct size, whereas a miRNA-21 inhibitor abolished this effect. Overall, these studies for the first time provide evidence for the potential role of endogenously synthesized miRNA's in cardioprotection following I/R injury. (c) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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