Journal
FEBS LETTERS
Volume 582, Issue 6, Pages 886-890Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.02.021
Keywords
endothelial cell; IL-1ra; proliferation
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Endothelial cell (EC) lifespan controlled by the IL-1 family of cytokines is an important determinant of susceptibility to artery wall disease. Here we show that EC lacking intracellular interleukin-1 receptor antagonist (IL-1ra) have a reduced lifespan compared to controls. Over expression of IL-1ra enhanced proliferation via cyclin dependent kinase 2 activity and retinoblastoma protein phosphorylation. This was not seen in EC lacking IL-1 receptor 1 (IL-1 signalling ability), nor apparent using other stimuli e.g. TNF alpha. These data suggest that IL-1ra has a specific and receptor-dependent function to control the growth and lifespan of EC. (C) 2008 Federation of European Biochemical Societies. Published by Else-tier B.V. All rights reserved.
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