4.5 Article

Atomic force microscopy reveals binding of mRNA to microtubules mediated by two major mRNP proteins YB-1 and PABP

Journal

FEBS LETTERS
Volume 582, Issue 19, Pages 2875-2881

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.07.019

Keywords

microtubule; RNA; RNP; atomic force microscopy; YB-1; PABP

Funding

  1. Russian Academy of Sciences
  2. French Embassy
  3. Association pour la Recherche sur le Cancer (ARC)

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A significant fraction of mRNAs is known to be associated in the form of mRNPs with microtubules for active transport. However, little is known about the interaction between mRNPs and microtubules and most of previous works were focused on molecular motor: microtubule interactions. Here, we have identified, via high resolution atomic force microscopy imaging, a significant binding of mRNA to microtubules mediated by two major mRNP proteins, YB-1 and PABP. This interaction with microtubules could be of critical importance for active mRNP traffic and for mRNP granule formation. A similar role may be fulfilled by other cationic mRNA partners. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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