Journal
FEBS LETTERS
Volume 583, Issue 2, Pages 437-442Publisher
WILEY
DOI: 10.1016/j.febslet.2008.12.043
Keywords
tRNA cleavage; Angiogenin; Stress
Funding
- Chinese Natural Science Foundation [30670440]
- Chinese State Key Project for Basic Research [2006CB910407, 2007CB914601]
- National 863 plans projects [2006AA02Z127]
Ask authors/readers for more resources
tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage event in mammalian cells. More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro and in vivo. These results imply that angiogenin plays an important physiological role in cell stress response, except for the known function of inducing angiogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available