Journal
FEBS LETTERS
Volume 582, Issue 14, Pages 1950-1959Publisher
WILEY
DOI: 10.1016/j.febslet.2008.04.014
Keywords
centromere; kinetochore; CENP-A; histone modifications
Funding
- Wellcome Trust [073915] Funding Source: Medline
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The centromere is a specialised region of the eukaryotic chromosome that directs the equal segregation of sister chromatids into two daughter cells during mitosis. In mitosis, the kinetochores mediate (1) microtubule capture and chromosome alignment at a metaphase plate; (2) the correction of improper microtubule attachments; (3) the maintenance of an active checkpoint until bi-orientation is achieved by the whole complement of chromosomes; (4) the establishment of tension within the centromere which, in turn, contributes to silencing of the spindle checkpoint and triggers the onset of anaphase. In this review, we will analyse how centromeres are organised with respect to chromatin types and arrangements. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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