Journal
FEBS LETTERS
Volume 582, Issue 8, Pages 1220-1224Publisher
WILEY
DOI: 10.1016/j.febslet.2008.02.015
Keywords
interactome; AP-MS; yeast two-hybrid; protein complex; systems biology; protein-protein interaction
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Cellular functions are almost always the result of the coordinated action of several proteins, interacting in protein complexes, pathways or networks. Progress made in devising suitable tools for analysis of protein-protein interactions, have recently made it possible to chart interaction networks on a large-scale. The aim of this review is to provide a short overview of the most promising contributions of interaction networks to human biology, structural biology and human genetics. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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