Journal
FEBS LETTERS
Volume 582, Issue 6, Pages 925-930Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.02.031
Keywords
eckol; ionizing radiation; radioprotection; mice
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We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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