Journal
FEBS LETTERS
Volume 582, Issue 19, Pages 2887-2892Publisher
WILEY
DOI: 10.1016/j.febslet.2008.07.024
Keywords
annular gap junction; clathrin; connexin; endocytosis; gap junction; RNAi
Funding
- NIHs NIGMS [GM55725]
- Bioengineering and Bioscience 2020 Funds
Ask authors/readers for more resources
Direct cell-cell communication mediated by plasma membrane-spanning gap junction (GJ) channels is vital to all aspects of cellular life. Obviously, GJ intercellular communication (GJIC) requires precise regulation, and it is known that controlled biosynthesis and degradation, and channel opening and closing (gating) are exploited. We discovered that cells internalize GJs in response to various stimuli. Here, we report that GJ internalization is a clathrin-mediated endocytic process that utilizes the vesicle-coat protein clathrin, the adaptor proteins adaptor protein complex 2 and disabled 2, and the GTPase dynamin. To our knowledge, we are first to report that the endocytic clathrin machinery can internalize double-membrane vesicles into cells. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available