Journal
FEBS LETTERS
Volume 582, Issue 19, Pages 2838-2842Publisher
WILEY
DOI: 10.1016/j.febslet.2008.07.012
Keywords
rab3; Zwint-1; rabphilin3a; SNAP25
Funding
- Netherlands Proteomics Centre
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Exocytic events are tightly regulated cellular processes in which rab GTPases and their interacting proteins perform an important function. We set out to identify new binding partners of rab3, which mediates regulated secretion events in specialized cells. We discovered Zwint-1 as a rab3 specific binding protein that bound preferentially to rab3c. The interaction depends on a critical residue in rab3c that determines the binding efficiency of Zwint-1, which is immaterial for interaction with rabphilin3a. Rab3c and Zwint-1 are expressed highly in brain and colocalized extensively in primary hippocampal neurons. We also found that SNAP25 bound to the same region in Zwint-1 as rab3c, suggesting a new role for the kinetochore protein Zwint-1 in presynaptic events that are regulated by rab3 and SNAP25. (C) 2008 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
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