Journal
FEBS LETTERS
Volume 582, Issue 21-22, Pages 3201-3205Publisher
WILEY
DOI: 10.1016/j.febslet.2008.08.011
Keywords
adipocyte differentiation; obesity; Wnt family; gene expression; 3T3-L1 cells; peroxisome proliferator-activated; receptor gamma
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Japan Society for the Promotion of Science (JSPS)
- Takeda Science Foundation
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The roles of the non-canonical Wnt pathway during adipogenesis are not well known, though Wnt10b is known to function as a negative regulator for adipogenesis by activating the canonical Wnt pathway. We focused on the roles of Wnt4, Wnt5a and Wnt6, which are thought to be part of the non-canonical Wnt pathway. The expression of these genes changed dramatically at the initial stage of adipogenesis. Furthermore, the inhibition of Wnt4 or Wnt5a expression prevented the accumulation of triacylglycerol and decreased the expression of adipogenesis-related genes. Wnt4 and Wnt5a have crucial roles in adipogenesis as positive regulators. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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