Journal
FEBS LETTERS
Volume 582, Issue 17, Pages 2643-2649Publisher
WILEY
DOI: 10.1016/j.febslet.2008.06.043
Keywords
DJ-1; secretion; oxidative stress; microdomain; Parkinson's disease
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DJ-1 is secreted into the serum and plasma of patients with various diseases. In this study, DJ-1 was found to be secreted into culture media of various cells and the amount of wild-type DJ-1 secreted was two-fold greater than that of mutant DJ-1 of cysteine at 106 (C106). Furthermore, the oxidative status of more than 90% of the DJ-1 secreted from HeLa cells was SOH and SO2H forms of C106. A portion of DJ-1 in cells was localized in microdomains of the membrane. These findings suggest that DJ-1 is secreted through microdomains and that oxidation of DJ-1 at C106 facilitates the secretion. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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