Journal
FEBS LETTERS
Volume 582, Issue 23-24, Pages 3451-3458Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.09.009
Keywords
Choroid; Neovascularization; Macular degeneration; Alcohol; Nicotine; Complement system
Funding
- NIH [EY 014623, EY 016205, 2 P20 RR 16460]
- Pat and Willard Walker Eye Research Center, Jones Eye Institute, University of Arkansas for Medical Sciences (Little Rock, AR)
- NIH/NCRR [1 S10 RR 19395]
Ask authors/readers for more resources
The objective of the present study was to investigate the effect of alcohol and nicotine consumption on the pathogenesis of choroidal neovascularization (CNV) in rats after laser-photocoagulation. Confocal microscopic analysis demonstrated an increase in CNV complex size in rats fed with alcohol (2.3-fold), nicotine (1.9-fold), and the combination of alcohol and nicotine (2.7-fold) compared with the control groups. Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
