Journal
FEBS LETTERS
Volume 582, Issue 23-24, Pages 3542-3546Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.09.032
Keywords
MicroRNA; Vitamin E; Tocopherol; Post-transcriptional gene regulation; Rat; Liver
Funding
- German Research Foundation (DFG) [(GRK 820)]
- Union zur Foerderung von Oel- und Proteinpflanzen (UFOP) e. V. [528/051]
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Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA-122a; cancer and inflammation, miRNA-125b). VE-deficiency resulted in reduced concentrations of miRNA-122a and miRNA-125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.
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