Journal
FEBS LETTERS
Volume 582, Issue 5, Pages 661-665Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.01.037
Keywords
14-3-3 protein; calmodulin; cAMP; protein kinase; signal transduction; proteomics
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Ca(2+)/calmodulin-dependent protein kinase kinase alpha (CaMKK alpha) plays critical roles in the modulation of neuronal cell survival as well as many other cellular activities. Here we show that 14-3-3 proteins directly regulate CaMKK alpha when the enzyme is phosphorylated by protein kinase A on either Ser74 or Ser475. Mutational analysis revealed that these two serines are both functional: the CaMKK alpha mutant with a mutation at either of these residues, but not the double mutant, was inhibited significantly by 14-3-3. The mode of regulation described herein differs the recently described mode of 14-3-3 regulation of CaMKK alpha. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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