Regulation of the human tRNase ZS gene expression

There are two types of tRNA 30 processing endoribonucleases ( tRNase Z): a short form ( tRNase Z S) and a long form ( tRNase Z L). Although the human genome contains both genes, little is known about the physiological role of tRNase Z S. We found that the human tRNase Z S gene expression appears to be post- transcriptionally regulated. Additionally, analyses for cis- regulatory elements for the tRNase Z S gene transcription suggested that transcription factors that bind to. ve di. erent sites on the promoter work together to potentiate the transcription initiation. Furthermore, we found that tRNase Z S is predominantly present in the cytosol and hardly in the nucleus. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.