Journal
FEBS LETTERS
Volume 582, Issue 13, Pages 1829-1834Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.04.047
Keywords
5-aminolevulinic acid synthase-1 (ALAS1); heme oxygenase-1 (HO-1); ethanol; gene expression; porphyria; rat liver
Funding
- NIAAA NIH HHS [R01 AA014891-01A1, R01 AA014891-02, AA014891, R01 AA014891] Funding Source: Medline
- NIDDK NIH HHS [R01 DK38825, U01DK065193] Funding Source: Medline
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5-Aminolevulinic acid synthase-1 (ALAS1) and heme oxygenase-1 (HO-1) are the rate-controlling enzymes for heme biosynthesis and degradation, respectively. Expression of these two genes showed tissue-specific expression pattern at both mRNA and protein levels in selected non-treated rat tissues. In the livers of rats receiving oral ethanol for 10 weeks, ALAS1 mRNA levels were increased by 65%, and the precursor and mature ALAS1 protein levels were increased by 1.8- and 2.3-fold, respectively, while no changes were observed in HO-1 mRNA and protein levels, compared with pair-fed controls. These results provide novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias. (c) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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