Journal
FEBS LETTERS
Volume 582, Issue 12, Pages 1755-1760Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.04.040
Keywords
vascular biology; transcription
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We show that transcription factor Kruppel-like factor 5 (KLF5), which is important in cardiovascular remodeling, interacts with retinoic acid receptor-alpha (RAR alpha) to regulate downstream gene expression. Here, we investigated whether acyclic retinoid (ACR) regulates KLF5 and inhibits vascular remodeling. Co-immunoprecipitation and pull-down binding assay showed that ACR attenuates functional interaction of KLF5 and RAR alpha. ACR affects KLF5 functions by regulating transactivation of platelet-derived growth factor A (PDGF-A) chain. ACR may be a new vascular therapy to target KLF5 in cardiovascular pathology. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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