Journal
FEBS LETTERS
Volume 582, Issue 12, Pages 1777-1782Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.04.031
Keywords
adiponectin; monocyte; type 2 diabetes; obesity
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The abundance of the adiponectin receptors, AdipoR1 and AdipoR2, and the effects of the antidiabetic adipokine adiponectin in monocytes of normal-weight and overweight controls and type 2 diabetic patients (T2D) were analyzed. AdipoR1 and AdipoR2 mRNAs were increased in monocytes of obese controls and T2D patients when compared to normal-weight controls, and AdipoR1 mRNA positively correlated to AdipoR2 mRNA, the waist to hip ratio and systemic adiponectin. However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal-weight donors. Induction of IL-6 and IL-8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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