Journal
FEBS LETTERS
Volume 582, Issue 17, Pages 2479-2483Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.06.031
Keywords
SIRT; Werner syndrome; longevity; caloric restriction
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Caloric restriction ( CR) is known to promote longevity in various species. Sirtuin- mediated deacetylation has been shown to be related to the promotion of longevity in some species. Here, we show that CR of rats led to an increase in the level of Werner syndrome protein ( WRN), a recognized DNA repair protein. In addition, CR simultaneously increased the level of SIRT1, a mammalian sirtuin. In HEK293T cells, sirtuin inhibitors decreased the WRN level, and this e. ect was suppressed by proteasomal inhibitors. Furthermore, we found a decrease in the WRN level in Sirt1- de. cient mice. These results indicate that sirtuin- mediated deacetylation stabilizes WRN.
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