Journal
FEBS LETTERS
Volume 582, Issue 30, Pages 4191-4196Publisher
WILEY
DOI: 10.1016/j.febslet.2008.11.020
Keywords
Aging; Male reproductive tract; Testis; Stress
Funding
- Fundacao para a Ciencia e Tecnologia, Portugal. [SFRH/BD/18734/2004, SFRH/BD/23643/2005]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/18734/2004, SFRH/BD/23643/2005] Funding Source: FCT
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To address the possibility that mitochondria are involved in the age-related loss of testicular function, we characterized mitochondrial bioenergetics in rat testis. A peak of mitochondrial functionality was detected in adult animals, with a decrease in both young and older animals. In the latter group a decrease in mitochondrial function was matched with an increase in proton leak and expression and activity of uncoupling protein 2 (UCP2), suggesting that proton leak may be involved in managing age-dependent mitochondrial dysfunction. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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