Journal
FEBS LETTERS
Volume 582, Issue 6, Pages 855-860Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2008.02.009
Keywords
Mcr1; mitochondria; outer membrane; protein import; signal-anchored protein
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The yeast gene MCR1 encodes two isoforms of the mitochondrial NADH-cytochrome b5 reductase. One form is embedded in the outer membrane whereas the other is located in the intermembrane space (IMS). In the present work we investigated the biogenesis of the outer membrane form. We demonstrate that while the IMS form crosses the outer membrane via the translocase of the outer mitochondrial membrane (TOM) complex, the other form is integrated into the outer membrane by a process that does not require any of the known import components at the outer membrane. Thus, the import pathways of the two forms diverge in a stage before the encounter with the TOM complex and their mechanism of biogenesis represents a unique example how to achieve dual localization within one organelle. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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