Journal
FEBS LETTERS
Volume 583, Issue 1, Pages 1-6Publisher
WILEY
DOI: 10.1016/j.febslet.2008.11.032
Keywords
Vascular permeability; Angiogenesis; VEGF; Adhesion; Cytoskeleton; Tight junctions
Funding
- Centre National de la Recherche Scientifique (CNRS)
- Projets Exploratoires/Premier Soutien (PEPS) program
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Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing factors (PIFs) was shown to elicit signaling mechanisms culminating in VE-cadherin destabilization and global alteration of the junctional architecture. Conversely, anti-PIFs protect from VE-cadherin disruption and enhance cell cohesion. These findings provide evidence on how endothelial cell-cell junctions impact the vascular network, and change our perception about normal and aberrant angiogenesis. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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