Journal
FEBS LETTERS
Volume 582, Issue 13, Pages 1877-1882Publisher
WILEY
DOI: 10.1016/j.febslet.2008.05.005
Keywords
AMF; MMP3; MAPK; JNK; metastasis
Funding
- NCI NIH HHS [R01 CA051714] Funding Source: Medline
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The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). The increase in MMP3 was found in an AMF-high production tumor cell line, and c-Jun, c-Fos and mitogen-activated protein kinases (MAPKs) were also highly phosphorylated compared with the parent line. AMF stimulation induced the rapid phosphorylation of the cellular MAPK cascade and MMP3 secretion, which was blocked using a specific MAPK inhibitor. Results of this study suggest that AMF stimulation stimulates MMP3 expression via a MAPK signaling pathway. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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