Journal
FEBS LETTERS
Volume 582, Issue 23-24, Pages 3396-3400Publisher
WILEY
DOI: 10.1016/j.febslet.2008.08.035
Keywords
Acute cerebral ischemia; Experimental therapy; Neuroprotection; Nuclear receptor; Transcriptional activator
Funding
- American Diabetes Association
- American Heart Association
Ask authors/readers for more resources
Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available