Journal
FEBS LETTERS
Volume 582, Issue 5, Pages 699-704Publisher
WILEY
DOI: 10.1016/j.febslet.2008.01.043
Keywords
antibiotics; antibacterial; avian eggshell; bacterial polysaccharides; C-type lectin
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C-type lectin-like proteins are major components of the calcified eggshell of multiple avian species. In this study, two representative avian C-type lectin-like proteins, ovocleidin-17 and ansocalcin, were purified from decalcified chicken and goose eggshell protein extracts and investigated for carbohydrate binding activity as well as antimicrobial activity. Purified ovocleidin-17 and ansocalcin were found to bind bacterial polysaccharides, and were bactericidal against Bacillus subtilis, Staphylococcus aureus and Pseudomona aeruginosa. Bactericidal activity was found to be enhanced in the presence of calcium but was not dependent on its presence. The results suggest that avian C-type lectin-like proteins may play an important antimicrobial role in defence of the avian embryo. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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