Journal
FEBS JOURNAL
Volume 282, Issue 9, Pages 1736-1744Publisher
WILEY
DOI: 10.1111/febs.13061
Keywords
cell differentiation; classIIa HDACs; development; HDAC4; HDAC5; HDAC7; HDAC9; immune system; metabolism; neuronal physiology and pathology; transcriptional repression
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Funding
- Spanish Ministry of Economy and Competitiveness (MINECO) [SAF2011-28290]
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HDAC4, 5, 7 and 9 constitute the classIIa histone deacetylases (HDACs) within the large family of protein deacetylases. ClassIIa HDACs have unique features that distinguish them from other HDACs. They contain an N-terminal domain that is required for their interaction with tissue-specific transcription factors and recruitment to their target genes. The N-terminal domain on classIIa HDACs also bears conserved serine residues that undergo signal-dependent phosphorylation, which brings about nuclear export of the enzymes and de-repression of their targets. One of the most important aspects of classIIa HDACs is their expression in specific tissues and organs within the organism, where they have crucial roles in development and differentiation processes. This review brings up to date our knowledge of the physiological and pathological functions of classIIa HDACs, focusing in particular on the most recent discoveries from invivo studies of mouse model systems.
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