Journal
FEBS JOURNAL
Volume 282, Issue 9, Pages 1723-1735Publisher
WILEY
DOI: 10.1111/febs.13083
Keywords
AEBP2; C17orf96; chromatin; epigenetics; gene expression; JARID2; polycomb; polycomb-like; RBAP46; 48; stem cells
Categories
Funding
- Beatriu de Pinos fellowship [BP-DGR2011 00099]
- Spanish Ministerio de Educacion y Ciencia [SAF2013-48926-P]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR)
- 'Fundacio' La Marato' [20131110]
- European Commission [277899]
- ICREA Funding Source: Custom
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The Polycomb group (PcG) of proteins form chromatin-binding complexes with histone-modifying activity. The two main PcG repressive complexes studied (PRC1 and PRC2) are generally associated with chromatin in its repressed state. PRC2 is responsible for methylation of histone H3 at lysine27 (H3K27me3), an epigenetic mark that is linked with numerous biological processes, including development, adult homeostasis and cancer. The core canonical complex PRC2, which contains the EZH1/2, SUZ12 and EED proteins, may be extended and functionally manipulated through interactions with several other proteins. In this review, we focus on these PRC2-associated proteins. As PRC2 functions are diverse, the variability conferred by these sub-stoichiometrically associated members may help to understand specific changes in PRC2 activity, chromatin recruitment and distribution required for gene repression.
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