Journal
FEBS JOURNAL
Volume 280, Issue 17, Pages 4004-4013Publisher
WILEY
DOI: 10.1111/febs.12189
Keywords
cell fate; glycolysis; metabolism; satellite cells; stem cells
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Funding
- Overseas Biomedical Research Fellowship from the National Health and Medical Research Council of Australia (NHMRC)
- Intramural Research Program of the National Institute of Arthritis, and Musculoskeletal and Skin diseases (NIAMS) at the National Institutes of Health (NIH, Bethesda, MD, USA)
- University of Melbourne (Melbourne, Victoria, Australia)
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Adult skeletal muscle contains a resident population of stem cells, termed satellite cells, that exist in a quiescent state. In response to an activating signal (such as physical trauma), satellite cells enter the cell cycle and undergo multiple rounds of proliferation, followed by differentiation, fusion, and maturation. Over the last 10-15years, our understanding of the transcriptional regulation of this stem cell population has greatly expanded, but there remains a dearth of knowledge with regard to the initiating signal leading to these changes in transcription. The recent renewed interest in the metabolic regulation of both cancer and stem cells, combined with previous findings indicating that satellite cells preferentially colocalize with blood vessels, suggests that satellite cell function may be regulated by changes in cellular metabolism. This review aims to describe what is currently known about satellite cell metabolism during changes in cell fate, as well as to describe some of the exciting findings in other cell types and how these might relate to satellite cells.
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