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Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species
Tian-Rui Xu et al.
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Small Molecule Screening in Zebrafish
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JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2010)
Interdependence of Gemcitabine Treatment, Transporter Expression, and Resistance in Human Pancreatic Carcinoma Cells
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NEOPLASIA (2010)
Fragment-Based Screening by Biochemical Assays: Systematic Feasibility Studies with Trypsin and MMP12
Andreas Boettcher et al.
JOURNAL OF BIOMOLECULAR SCREENING (2010)
High-Content Screening: A Decade of Evolution
Nick Thomas
JOURNAL OF BIOMOLECULAR SCREENING (2010)
Effects of Drug Transporters on Volume of Distribution
Anita Grover et al.
AAPS JOURNAL (2009)
Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics
M. Brown et al.
ANALYST (2009)
Network analyses in systems pharmacology
Seth I. Berger et al.
BIOINFORMATICS (2009)
Siderophore production by marine-derived fungi
Brian Holinsworth et al.
BIOMETALS (2009)
Physiochemical property space distribution among human metabolites, drugs and toxins
Varun Khanna et al.
BMC BIOINFORMATICS (2009)
Automated genome mining for natural products
Michael H. T. Li et al.
BMC BIOINFORMATICS (2009)
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
Douglas B. Kell
BMC MEDICAL GENOMICS (2009)
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Nathan R. Perron et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2009)
Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds
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CHEMMEDCHEM (2009)
Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma
Raphael Marechal et al.
CLINICAL CANCER RESEARCH (2009)
Applications of High Content Screening in Life Science Research
Joseph M. Zock
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2009)
Exploring the chemical space of microbial natural products
Hiroyuki Osada et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2009)
Implications of the Dominant Role of Transporters in Drug Uptake by Cells
Paul D. Dobson et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
Automation in High-Content Flow Cytometry Screening
U. Naumann et al.
CYTOMETRY PART A (2009)
Revealing promiscuous drug-target interactions by chemical proteomics
Marcus Bantscheff et al.
DRUG DISCOVERY TODAY (2009)
'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries
Paul D. Dobson et al.
DRUG DISCOVERY TODAY (2009)
Role of membrane transporters in the safety profile of drugs
Edmund Jon Deoon Lee et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion
Yurong Lai
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Physicochemical drug properties associated with in vivo toxicological outcomes: a review
David A. Price et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer
James J. Farrell et al.
GASTROENTEROLOGY (2009)
Chemoinformatic Analysis of Combinatorial Libraries, Drugs, Natural Products, and Molecular Libraries Small Molecule Repository
Narender Singh et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2009)
Novel Chemical Space Exploration via Natural Products
Josefin Rosen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
From structure to dynamics: Frequency tuning in the p53-Mdm2 network I. Logical approach
Wassim Abou-Jaoude et al.
JOURNAL OF THEORETICAL BIOLOGY (2009)
Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity
Keunwan Park et al.
MOLECULAR BIOSYSTEMS (2009)
The topology of drug-target interaction networks: implicit dependence on drug properties and target families
Jordi Mestres et al.
MOLECULAR BIOSYSTEMS (2009)
Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients
Petrine Wellendorph et al.
MOLECULAR PHARMACOLOGY (2009)
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor
Harish Shankaran et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
Applications of genome-scale metabolic reconstructions
Matthew A. Oberhardt et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
DRUG DISCOVERY Predicting promiscuity
Andrew L. Hopkins
NATURE (2009)
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
NATURE (2009)
Synergistic drug combinations tend to improve therapeutically relevant selectivity
Joseph Lehar et al.
NATURE BIOTECHNOLOGY (2009)
A proteomics approach to discovering natural products and their biosynthetic pathways
Stefanie B. Bumpus et al.
NATURE BIOTECHNOLOGY (2009)
Bioactivity-guided mapping and navigation of chemical space
Steffen Renner et al.
NATURE CHEMICAL BIOLOGY (2009)
HMDB: a knowledgebase for the human metabolome
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2009)
Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies
Michael V. Holmes et al.
PLOS ONE (2009)
Unfaithful neurotransmitter transporters: Focus on serotonin uptake and implications for antidepressant efficacy
Lynette C. Daws
PHARMACOLOGY & THERAPEUTICS (2009)
Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription
Louise Ashall et al.
SCIENCE (2009)
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
Jesse W. -H. Li et al.
SCIENCE (2009)
Update on statin-mediated anti-inflammatory activities in atherosclerosis
Fabrizio Montecucco et al.
SEMINARS IN IMMUNOPATHOLOGY (2009)
The Application of Phenotypic High-Throughput Screening Techniques to Cardiovascular Research
Yoram Etzion et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2009)
Conciliating binding efficiency and polypharmacology
Jordi Mestres et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Systems pharmacology and genome medicine: a future perspective
Aislyn D. Wist et al.
GENOME MEDICINE (2009)
Systems medicine: the future of medical genomics and healthcare
Charles Auffray et al.
GENOME MEDICINE (2009)
Identification of a Topological Characteristic Responsible for the Biological Robustness of Regulatory Networks
Yangle Wu et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism
James Corey Adams et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening
Maha-Hamadien Abdulla et al.
PLOS NEGLECTED TROPICAL DISEASES (2009)
Immunomodulatory and Anti-Inflammatory Activities of Statins
Emilia Mira et al.
Endocrine Metabolic & Immune Disorders-Drug Targets (2009)
Natural products as a robust source of new drugs and drug leads: Past successes and present day issues
Gilbert M. Rishton
AMERICAN JOURNAL OF CARDIOLOGY (2008)
Adenoviral-mediated overexpression of human equilibrative nucleoside transporter 1 (hENT1) enhances gemcitabine response in human pancreatic cancer
Sandra Perez-Torras et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Genetic screening for novel Drosophila mutants with discrepancies in iron metabolism
Anuja Mehta et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
BioBayes: A software package for Bayesian inference in systems biology
Vladislav Vyshemirsky et al.
BIOINFORMATICS (2008)
Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo
Bayu Jayawardhana et al.
BIOINFORMATICS (2008)
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
Gavin A. Whitlock et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The state of innovation in drug development
I. Kola
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
A ligand-based approach to mining the chemogenomic space of drugs
Elisabet Gregori-Puigjane et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2008)
Sloppiness, robustness, and evolvability in systems biology
Bryan C. Daniels et al.
CURRENT OPINION IN BIOTECHNOLOGY (2008)
The impact of natural products upon modern drug discovery
A. Ganesan
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Human metabolic network reconstruction and its impact on drug discovery and development
Hongwu Ma et al.
DRUG DISCOVERY TODAY (2008)
Natural products in drug discovery
Alan L. Harvey
DRUG DISCOVERY TODAY (2008)
Interindividual variability in oral antidiabetic drug disposition and response: the role of drug transporter polymorphisms
Michael A. Pacanowski et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Natural product-likeness score and its application for prioritization of compound libraries
Peter Ertl et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)
Genome mining for novel natural product discovery
Gregory L. Challis
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Proximate parameter tuning for biochemical networks with uncertain kinetic parameters
Stephen J. Wilkinson et al.
MOLECULAR BIOSYSTEMS (2008)
High-order combination effects and biological robustness
Joseph Lehar et al.
MOLECULAR SYSTEMS BIOLOGY (2008)
Scaffold diversity of natural products: inspiration for combinatorial library design
Kristina Grabowski et al.
NATURAL PRODUCT REPORTS (2008)
Natural products to drugs: natural product-derived compounds in clinical trials
Mark S. Butler
NATURAL PRODUCT REPORTS (2008)
A network solution
Adriano Henney et al.
NATURE (2008)
Frequency-modulated nuclear localization bursts coordinate gene regulation
Long Cai et al.
NATURE (2008)
Large-scale chemical dissection of mitochondrial function
Bridget K. Wagner et al.
NATURE BIOTECHNOLOGY (2008)
A quantitative analysis of kinase inhibitor selectivity
Mazen W. Karaman et al.
NATURE BIOTECHNOLOGY (2008)
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
Markus J. Herrgard et al.
NATURE BIOTECHNOLOGY (2008)
Chemical biology and the limits of reductionism
Randall T. Peterson
NATURE CHEMICAL BIOLOGY (2008)
Network pharmacology: the next paradigm in drug discovery
Andrew L. Hopkins
NATURE CHEMICAL BIOLOGY (2008)
Opinion - Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
Paul D. Dobson et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Paul M. Ridker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
The virtual physiological human: building a framework for computational biomedicine
Gordon Clapworthy et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2008)
Patient-specific simulation as a basis for clinical decision-making
S. Kashif Sadiq et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2008)
Protein area occupancy at the center of the red blood cell membrane
Allison D. Dupuy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Drug target identification using side-effect similarity
Monica Campillos et al.
SCIENCE (2008)
Caenorhabditis elegans:: An emerging model in biomedical and environmental toxicology
Maxwell C. K. Leung et al.
TOXICOLOGICAL SCIENCES (2008)
Application of systems biology for bioprocess development
Jin Hwan Park et al.
TRENDS IN BIOTECHNOLOGY (2008)
Role of transport proteins in drug discovery and development: a pharmaceutical perspective
A. Ayrton et al.
XENOBIOTICA (2008)
Fragment-based approach to drug lead discovery - Overview and advances in various techniques
Daniela Fattori et al.
DRUGS IN R&D (2008)
Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus
Diluka Peiris et al.
METABOLOMICS (2008)
Bayesian ranking of biochemical system models
Vladislav Vyshemirsky et al.
BIOINFORMATICS (2008)
Integrating high-content screening and ligand-target prediction to identify mechanism of action
Daniel W. Young et al.
NATURE CHEMICAL BIOLOGY (2008)
Accurate automated log Po/w measurement by gradient-flow liquid-liquid partition chromatography Part 1.: Neutral compounds
Sandrine Demare et al.
JOURNAL OF CHROMATOGRAPHY A (2007)
Drug discovery beyond the 'rule-of-five'
Ming-Qiang Zhang et al.
CURRENT OPINION IN BIOTECHNOLOGY (2007)
A Sorcerer's apprentice and the rule of five: from rule-of-thumb to commandment and beyond
Cele Abad-Zapatero
DRUG DISCOVERY TODAY (2007)
The influence of drug-like concepts on decision-making in medicinal chemistry
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer
Tetsuya Oguri et al.
CANCER LETTERS (2007)
Drug-target network
Muhammed A. Yildirim et al.
NATURE BIOTECHNOLOGY (2007)
The Edinburgh human metabolic network reconstruction and its functional analysis
Hongwu Ma et al.
MOLECULAR SYSTEMS BIOLOGY (2007)
Metabolite essentiality elucidates robustness of Escherichia coli metabolism
Pan-Jun Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A comparison of the chemical properties of drugs and FEMA/FDA notified GRAS chemical compounds used in the food industry
D. G. Sprous et al.
FOOD AND CHEMICAL TOXICOLOGY (2007)
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum
Shigeki Yoshiura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Automated reverse engineering of nonlinear dynamical systems
Josh Bongard et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Modeling promiscuity based on in vitro safety pharmacology profiling data
Kamal Azzaoui et al.
CHEMMEDCHEM (2007)
Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
Jin Hwan Park et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
Y. Nakano et al.
BRITISH JOURNAL OF CANCER (2007)
Global reconstruction of the human metabolic network based on genomic and bibliomic data
Natalie C. Duarte et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Fragments, network biology and designing multiple ligands
Richard Morphy et al.
DRUG DISCOVERY TODAY (2007)
Relating protein pharmacology by ligand chemistry
Michael J. Keiser et al.
NATURE BIOTECHNOLOGY (2007)
Comparing the chemical spaces of metabolites and available chemicals: models of metabolite-likeness
Sunil Gupta et al.
MOLECULAR DIVERSITY (2007)
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox
Scott A. Becker et al.
NATURE PROTOCOLS (2007)
The value of natural products to future pharmaceutical discovery
Dwight D. Baker et al.
NATURAL PRODUCT REPORTS (2007)
Fragment-based drug discovery: What has it achieved so fair?
Alexander A. Alex et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
Natural products as sources of new drugs over the last 25 years
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Oscillations and temporal signalling in cells
G. Tiana et al.
PHYSICAL BIOLOGY (2007)
Lead-like, drug-like or pub-like: how different are they?
Tudor I. Oprea et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)
Multi-target therapeutics: when the whole is greater than the sum of the parts
Grant R. Zimmermann et al.
DRUG DISCOVERY TODAY (2007)
A decade of fragment-based drug design: strategic advances and lessons learned
Philip J. Hajduk et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Innovation - A robustness-based approach to systems-oriented drug design
Hiroaki Kitano
NATURE REVIEWS DRUG DISCOVERY (2007)
Systems biology, metabolic modelling and metabolomics in drug discovery and development
Douglas B. Kell
DRUG DISCOVERY TODAY (2006)
Statistical strategies for avoiding false discoveries in metabolomics and related experiments
David I. Broadhurst et al.
METABOLOMICS (2006)
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
James J. Collins et al.
EXPERIMENTAL GERONTOLOGY (2006)
Fragment screening: an introduction
Andrew R. Leach et al.
MOLECULAR BIOSYSTEMS (2006)
Global mapping of pharmacological space
Gaia V. Paolini et al.
NATURE BIOTECHNOLOGY (2006)
TarFisDock: a web server for identifying drug targets with docking approach
Honglin Li et al.
NUCLEIC ACIDS RESEARCH (2006)
Dependence of molecular properties on proteomic family for marketed oral drugs
Michal Vieth et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Single-cell proteomic analysis of S-cerevisiae reveals the architecture of biological noise
John R. S. Newman et al.
NATURE (2006)
Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
Richard H. Ho et al.
GASTROENTEROLOGY (2006)
Transporters as a determinant of drug clearance and tissue distribution
Y Shitara et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
E Giovannetti et al.
CANCER RESEARCH (2006)
Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells
DB Kell
FEBS JOURNAL (2006)
Can we rationally design promiscuous drugs?
AL Hopkins et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2006)
High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans
Andrew R. Burns et al.
NATURE PROTOCOLS (2006)
Oscillations and variability in the p53 system
Naama Geva-Zatorsky et al.
MOLECULAR SYSTEMS BIOLOGY (2006)
Drug discovery from natural sources
Young-Won Chin et al.
AAPS JOURNAL (2006)
Visualization and interpretation of high content screening data
A Smellie et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)
Systems biology, connectivity and the future of medicine
J van der Greef
IEE PROCEEDINGS SYSTEMS BIOLOGY (2005)
Innovation -: Rescuing drug discovery:: in vivo systems pathology and systems pharmacology
J van der Greef et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Metabolomics reviewed: A new Omics platform technology for systems biology and implications for natural products research
S Rochfort
JOURNAL OF NATURAL PRODUCTS (2005)
Analysis of drug-induced effect patterns to link structure and side effects of medicines
AF Fliri et al.
NATURE CHEMICAL BIOLOGY (2005)
Identifying biologically active compound classes using phenotypic screening data and sampling statistics
J Klekota et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)
Systems cell biology knowledge created from high content screening
KA Giuliano et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2005)
Fast determination of lipophilicity by HPLC
L Ayouni et al.
CHROMATOGRAPHIA (2005)
Synergistic control of oscillations in the NF-κB signalling pathway
AEC Ihekwaba et al.
IEE PROCEEDINGS SYSTEMS BIOLOGY (2005)
Nonlinear system identification using coevolution of models and tests
JC Bongard et al.
IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION (2005)
Expanding the ChemGPS chemical space with natural products
J Larsson et al.
JOURNAL OF NATURAL PRODUCTS (2005)
High content screening for G protein-coupled receptors using cell-based protein translocation assays
C Grånäs et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2005)
Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
P Anderle et al.
BMC GENOMICS (2005)
Finding the target after screening the phenotype
CP Hart
DRUG DISCOVERY TODAY (2005)
Robustness, evolvability, and neutrality
A Wagner
FEBS LETTERS (2005)
Protein families and their evolution - A structural perspective
CA Orengo et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2005)
Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
CY Wu et al.
PHARMACEUTICAL RESEARCH (2005)
High-content screening and profiling of drug activity in an automated centrosome-duplication assay
ZE Perlman et al.
CHEMBIOCHEM (2005)
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
BL Roth et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
A new accident model for engineering safer systems
N Leveson
SAFETY SCIENCE (2004)
Predicting undesirable drug interactions with promiscuous proteins in silico
S Ekins
DRUG DISCOVERY TODAY (2004)
Dynamics of the p53-Mdm2 feedback loop in individual cells
G Lahav et al.
NATURE GENETICS (2004)
Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast
G Giaever et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Robustness of cellular functions
J Stelling et al.
CELL (2004)
Fragment-based lead discovery
DC Rees et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Flow cytometry for high-throughput, high-content screening
BS Edwards et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells
DB Wheeler et al.
NATURE METHODS (2004)
Oscillations in NF-κB signaling control the dynamics of gene expression
DE Nelson et al.
SCIENCE (2004)
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
J Spratlin et al.
CLINICAL CANCER RESEARCH (2004)
Complex phenotypic assays in high-throughput screening
PA Clemons
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
High content screening applied to large-scale cell biology
VC Abraham et al.
TRENDS IN BIOTECHNOLOGY (2004)
Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era
DB Kell et al.
BIOESSAYS (2004)
Global analysis of protein expression in yeast
S Ghaemmaghami et al.
NATURE (2003)
Advances in high content screening for drug discovery
KA Giuliano et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2003)
Metabolic pathways in the post-genome era
JA Papin et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Property distributions: Differences between drugs, natural products, and molecules from combinatorial chemistry
M Feher et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2003)
Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
P Libby et al.
NATURE MEDICINE (2002)
Robustness as a measure of plausibility in models of biochemical networks
M Morohashi et al.
JOURNAL OF THEORETICAL BIOLOGY (2002)
Prediction of 'drug-likeness'
WP Walters et al.
ADVANCED DRUG DELIVERY REVIEWS (2002)
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
CM Grozinger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
High content screening - from cells to data to knowledge
C Liptrot
DRUG DISCOVERY TODAY (2001)
Robustness as an evolutionary principle
S Bornholdt et al.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2000)
Small molecule developmental screens reveal the logic and timing of vertebrate development
RT Peterson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
The segment polarity network is a robust developmental module
G von Dassow et al.
NATURE (2000)
De novo design of molecular architectures by evolutionary assembly of drug-derived building blocks
G Schneider et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2000)