Journal
FEBS JOURNAL
Volume 280, Issue 20, Pages 4999-5014Publisher
WILEY
DOI: 10.1111/febs.12353
Keywords
cell death; complexI; cytochromec; mitochondria; oxidative phosphorylation
Categories
Funding
- European Social Fund under the Global Grant Measure [VP1-3.1-SMM-07-K-01-130]
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We review research investigating mitochondrial damage during heart and brain ischaemia, focusing on the mechanisms and consequences of ischaemia-induced and/or reperfusion-induced: (a) inhibition of mitochondrial respiratory complexI; (b) release of cytochromec from mitochondria; (c) changes to mitochondrial phospholipids; and (d) nitric oxide inhibition of mitochondria. Heart ischaemia causes inhibition of cytochrome oxidase and complexI, release of cytochromec, and induction of permeability transition and hydrolysis and oxidation of mitochondrial phospholipids, but some of the mechanisms are unclear. Brain ischaemia causes inhibition of complexesI and IV, but other effects are less clear.
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