Journal
FEBS JOURNAL
Volume 280, Issue 2, Pages 505-524Publisher
WILEY
DOI: 10.1111/j.1742-4658.2012.08565.x
Keywords
cancer; cell signalling; dual specificity phosphatases; metastasis; phosphatase of regenerating liver; protein phosphatases
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Funding
- German Science Foundation (Deutsche Forschungsgemeinschaft, DFG) within the Emmy-Noether program
- EMBL
- Marie Curie Action EMBL Interdisciplinary Postdoc fellowships
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The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase. Finally, we discuss similarities and differences between the phosphatases of regenerating liver, focusing on their molecular mechanisms and signalling pathways.
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