Journal
FEBS JOURNAL
Volume 279, Issue 19, Pages 3538-3548Publisher
WILEY
DOI: 10.1111/j.1742-4658.2012.08699.x
Keywords
cancer; DLG1; expression; MAGI-1; Par; PDZ; polarity; regulation; Scribble; Zo-1
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Funding
- Agencia de Promocion Cientifica y Tecnologica (Argentina) [PICT2008-0421]
- Province of Santa Fe, Argentin
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The general features of the PDZ domain structure and functions have been extensively studied during the last decade. PDZ domains are generally present in proteins that are involved in multiple interactions to assemble functional protein complexes that control key cellular processes. One of the best characterized functions of PDZ domain-containing proteins is control of epithelial cell polarity and cellcell contacts. In the present review, we summarize the current knowledge on regulation of expression of certain PDZ polarity proteins localized at the intercellular junctions. In addition, we provide a critical overview of recent findings regarding the role of these proteins during development of human diseases. Complete understanding of these issues is valuable for the design of novel therapeutic intervention for common pathologies, such as cancer.
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