Journal
FEBS JOURNAL
Volume 279, Issue 15, Pages 2598-2609Publisher
WILEY
DOI: 10.1111/j.1742-4658.2012.08651.x
Keywords
cancer; leukemia; lymphocytes; lymphoma; metabolism
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Recent studies of normal and neoplastic lymphocytes have revealed overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is attenuated in normal lymphocytes that return to the basal state, but Notch-activated or Myc-transformed lymphocytes persistently express Myc, which activates genes involved in glucose and glutamine metabolism. Although this difference could provide a therapeutic window for the treatment of cancers, the overlapping metabolic profiles suggest a potential for immunosuppression by metabolic inhibitors.
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