Journal
FEBS JOURNAL
Volume 278, Issue 11, Pages 1808-1817Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1742-4658.2011.08082.x
Keywords
ANF; atrial natriuretic peptide (ANP); B-type natriuretic peptide (BNP); cardiovascular disease; cGMP; endochondrial ossification; neprilysin; proteolysis; receptor internalization
Categories
Funding
- National Institutes of Health [NIHR21HL093402]
- American Heart Association [0950053G]
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Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C.
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