Journal
FEBS JOURNAL
Volume 278, Issue 20, Pages 3846-3858Publisher
WILEY
DOI: 10.1111/j.1742-4658.2011.08185.x
Keywords
biogenesis; insertion; membrane protein; translocon; transmembrane segment
Categories
Funding
- Spanish Ministry of Science and Innovation [BFU2009-08401/BMC, BFU2010-19310/BMC]
- Generalitat Valenciana [PROMETEO/2010/005, ACOMP/2011/025, ACOMP/2011/048]
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Most integral membrane proteins are targeted, inserted and assembled in the endoplasmic reticulum membrane. The sequential and potentially overlapping events necessary for membrane protein integration take place at sites termed translocons, which comprise a specific set of membrane proteins acting in concert with ribosomes and, probably, molecular chaperones to ensure the success of the whole process. In this minireview, we summarize our current understanding of helical membrane protein integration at the endoplasmic reticulum, and highlight specific characteristics that affect the biogenesis of multispanning membrane proteins.
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