Journal
FEBS JOURNAL
Volume 278, Issue 13, Pages 2182-2210Publisher
WILEY
DOI: 10.1111/j.1742-4658.2011.08128.x
Keywords
chromatin; DNase I hypersensitive; gene regulation; nucleosome; transcription
Categories
Funding
- Leukaemia and Lymphoma Research
- Biotechnology and Biological Sciences Research Council
- Yorkshire Cancer Research
- Biotechnology and Biological Sciences Research Council [BB/E023002/1] Funding Source: researchfish
- BBSRC [BB/E023002/1] Funding Source: UKRI
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Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription factors and acts as a barrier to polymerases. Therefore the complex process of gene activation must operate at two levels. In the first instance, localized chromatin decondensation and nucleosome displacement is required to make DNA accessible. Second, sequence-specific transcription factors need to recruit chromatin modifiers and remodellers to create a chromatin environment that permits the passage of polymerases. In this review I will discuss the chromatin structural changes that occur at active gene loci and at regulatory elements that exist as DNase I hypersensitive sites.
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