Related references
Note: Only part of the references are listed.Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A Botulinum Neurotoxin Protease Activity
Martha Hale et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner
Jasmin Strotmeier et al.
BIOCHEMICAL JOURNAL (2010)
Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA
Andrew P. -A. Karalewitz et al.
BIOCHEMISTRY (2010)
Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding
Pal Stenmark et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A
Jorge E. Zuniga et al.
PLOS ONE (2010)
SV2 Mediates Entry of Tetanus Neurotoxin into Central Neurons
Felix L. Yeh et al.
PLOS PATHOGENS (2010)
Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A
Virginia Roxas-Duncan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: Effects of zinc ion and peptides on inhibition
Huiguo Lai et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2009)
Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A
Geoffrey Masuyer et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane
Lucia Muraro et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F
Zhuji Fu et al.
BIOCHEMISTRY (2009)
Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation
Desigan Kumaran et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Cell entry strategy of clostridial neurotoxins
Thomas Binz et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F
Rakhi Agarwal et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design
Yuan-Ping Pang et al.
PLOS ONE (2009)
Bimodal modulation of the botulinum neurotoxin protein-conducting channel
Audrey Fischer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Engineering botulinum neurotoxin to extend therapeutic intervention
Sheng Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins
Katerina Capkova et al.
TOXICON (2009)
Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel
Mauricio Montal
TOXICON (2009)
Catalytic features of the botulinum neurotoxin a light chain revealed by high resolution structure of an inhibitory peptide complex
Nicholas R. Silvaggi et al.
BIOCHEMISTRY (2008)
SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E
Rakhi Agarwal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype A
Desigan Kumaran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins
Stefan Sikorra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics
Jiafu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Membrane interaction of botulinum neurotoxin A translocation (T) domain - The belt region is a regulatory loop for membrane interaction
Marie Galloux et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Glycosylated SV2A and SV2B Mediate the Entry of Botulinum Neurotoxin E into Neurons
Min Dong et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D
Kentaro Tsukamoto et al.
MICROBIAL PATHOGENESIS (2008)
A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate
Jorge E. Zuniga et al.
STRUCTURE (2008)
Crystal structure of botulinum neurotoxin type a in complex with the cell surface co-receptor GT1b - Insight into the toxin-neuron interaction
Pal Stenmark et al.
PLOS PATHOGENS (2008)
Substrate binding mode and its implication on drug design for botulinum neurotoxin A
Desigan Kumaran et al.
PLOS PATHOGENS (2008)
Botulinum Neurotoxin Devoid of Receptor Binding Domain Translocates Active Protease
Audrey Fischer et al.
PLOS PATHOGENS (2008)
Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy
Audrey Fischer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons
Min Dong et al.
JOURNAL OF CELL BIOLOGY (2007)
Crucial role of the disulfide bridge between botulinum neurotoxin light and heavy chains in protease translocation across membranes
Audrey Fischer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: Implications for dual substrate specificity
Rongsheng Jin et al.
BIOCHEMISTRY (2007)
Computer-Aided Lead Optimization: Improved Small-Molecule Inhibitor of the Zinc Endopeptidase of Botulinum Neurotoxin Serotype A
Jing Tang et al.
PLOS ONE (2007)
A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype a metalloprotease
James C. Burnett et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Structures of Clostridium botulinum neurotoxin serotype a light chain complexed with small-molecule inhibitors highlight active-site flexibility
Nicholas R. Silvaggi et al.
CHEMISTRY & BIOLOGY (2007)
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons
James C. Burnett et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification of the protein receptor binding site of botulinum neurotoxins B and G oroves the double-receptor concept
Andreas Rummel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Qing Chai et al.
NATURE (2006)
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Rongsheng Jin et al.
NATURE (2006)
SV2 is the protein receptor for botulinum neurotoxin A
M Dong et al.
SCIENCE (2006)
Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin
S Jayaraman et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)
Structural analysis of botulinum neurotoxin serotype F light chain: Implications on substrate binding and inhibitor design
R Agarwal et al.
BIOCHEMISTRY (2005)
Crystal structure of botulinum neurotoxin type G light chain: Serotype divergence in substrate recognition
JW Arndt et al.
BIOCHEMISTRY (2005)
Analysis of active site residues of botulinum neurotoxin E by mutational, functional, and structural studies: Glu335Gln is an apoenzyme
R Agarwal et al.
BIOCHEMISTRY (2005)
Structural analysis of the catalytic domain of tetanus neurotoxin
KN Rao et al.
TOXICON (2005)
2.3 Å crystal structure of tetanus neurotoxin light chain
MA Breidenbach et al.
BIOCHEMISTRY (2005)
The evolving field of biodefence: Therapeutic developments and diagnostics
JC Burnett et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Botulinum neurotoxin serotype F: Identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity
JJ Schmidt et al.
BIOCHEMISTRY (2005)
Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding
JC Burnett et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Role of metals in the biological activity of clostridium botulinum neurotoxins
S Eswaramoorthy et al.
BIOCHEMISTRY (2004)
Structure and enzymatic activity of botulinum neurotoxins
S Swaminathan et al.
MOVEMENT DISORDERS (2004)
Deciphering antibody properties that lead to potent botulinum neurotoxin neutralization
JD Marks
MOVEMENT DISORDERS (2004)
The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction
A Rummel et al.
MOLECULAR MICROBIOLOGY (2004)
Substrate recognition strategy for botulinum neurotoxin serotype A
MA Breidenbach et al.
NATURE (2004)
Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212→Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway
R Agarwal et al.
BIOCHEMISTRY (2004)
Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state:: Evidence for noncanonical zinc protease activity
B Segelke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
JC Burnett et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
M Dong et al.
JOURNAL OF CELL BIOLOGY (2003)
Two carbohydrate binding sites in the Hcc-domain of tetanus neurotoxin are required for toxicity
A Rummel et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Translocation of botulinum neurotoxin light chain protease through the heavy chain channel
LK Koriazova et al.
NATURE STRUCTURAL BIOLOGY (2003)
A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity
JJ Schmidt et al.
FEBS LETTERS (2002)
Arg362 and Tyr365 of the botulinum neurotoxin type a light chain are involved in transition state stabilization
T Binz et al.
BIOCHEMISTRY (2002)
Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B
S Eswaramoorthy et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2001)
The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin
C Fotinou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The role of zinc binding in the biological activity of botulinum toxin
LL Simpson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B
S Swaminathan et al.
NATURE STRUCTURAL BIOLOGY (2000)
The structures of the HC fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding
P Emsley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Identification of novel small molecule ligands that bind to tetanus toxin
FC Lightstone et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2000)