Journal
FEBS JOURNAL
Volume 278, Issue 12, Pages 1970-1979Publisher
WILEY
DOI: 10.1111/j.1742-4658.2011.08074.x
Keywords
development; ERK; Id3; Interleukin-4; PLC; PLZF; SLP-76; signaling; T-bet; T cell receptor
Categories
Funding
- National Institutes of Health [AI51626, AI065566, AI073955]
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The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase (Itk) is predominantly expressed in T cells and has been shown to be critical for the development, function and differentiation of conventional alpha beta T cells. However, less is known about its role in nonconventional T cells such as NKT and gamma delta T cells. In this minireview, we discuss evidence for a role for Itk in the development of invariant NKT alpha beta cells, as well as a smaller population NKT-like gamma delta T cells. We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function.
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