Journal
FEBS JOURNAL
Volume 277, Issue 21, Pages 4356-4369Publisher
WILEY
DOI: 10.1111/j.1742-4658.2010.07865.x
Keywords
Dok; DOS; FRS2; Gab; IRS; protein modules; protein phosphorylation; SH2; signal transduction; tyrosine kinase
Categories
Funding
- German Research Foundation
- National Health and Medical Research Council of Australia
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Docking proteins comprise a distinct category of intracellular, noncatalytic signalling protein, that function downstream of a variety of receptor and receptor-associated tyrosine kinases and regulate diverse physiological and pathological processes. The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category. This minireview focuses on the structure, function and regulation of these proteins.
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