Journal
FEBS JOURNAL
Volume 277, Issue 19, Pages 3864-3875Publisher
WILEY
DOI: 10.1111/j.1742-4658.2010.07797.x
Keywords
biglycan; cancer; decorin; EGFR; IGF-IR; inflammation; lumican; Met; signal transduction; Toll-like receptor
Categories
Funding
- National Institutes of Health [RO1 CA39481, RO1 CA47282, RO1 CA120975]
- Deutsche Forschungsgemeinschaft [SCHA 1082/2-1]
- Else Kroner-Fresenius-Stiftung
- NATIONAL CANCER INSTITUTE [R01CA047282, R01CA039481, R01CA120975] Funding Source: NIH RePORTER
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The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease. They are now being recognized as key signaling molecules with an expanding repertoire of molecular interactions affecting not only growth factors, but also various receptors involved in controlling cell growth, morphogenesis and immunity. The complexity of SLRP signaling and the multitude of affected signaling pathways can be reconciled with a hierarchical affinity-based interaction of various SLRPs in a cell- and tissue-specific context. Here, we review this interacting network, describe new relationships of the SLRPs with tyrosine kinase and Toll-like receptors and critically assess their roles in cancer and innate immunity.
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