Journal
FEBS JOURNAL
Volume 277, Issue 17, Pages 3459-3469Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1742-4658.2010.07759.x
Keywords
Bcl-2; c-Myc; DNA secondary structures; G-quadruplex; gene expression; i-motif; NM23-H2; nucleolin; promoter; supercoiling
Categories
Funding
- National Institutes of Health [CA95060, GM085585, CA153821 T32CA09213]
- Leukemia & Lymphoma Society [6225-08]
- NATIONAL CANCER INSTITUTE [R01CA153821, P30CA023074, P50CA095060, T32CA009213] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM085585] Funding Source: NIH RePORTER
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The presence and biological importance of DNA secondary structures in eukaryotic promoters are becoming increasingly recognized among chemists and biologists as bioinformatics in vitro and in vivo evidence for these structures in the c-Myc, c-Kit, KRAS, PDGF-A, hTERT, Rb, RET and Hif-1 alpha promoters accumulates. Nevertheless, the evidence remains largely circumstantial. This minireview differs from previous ones in that here we examine the diversity of G-quadruplex and i-motif structures in promoter elements and attempt to categorize the different types of arrangements in which they are found. For the c-Myc G-quadruplex and Bcl-2 i-motif, we summarize recent biological and structural studies.
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