Journal
FEBS JOURNAL
Volume 277, Issue 5, Pages 1107-1117Publisher
WILEY
DOI: 10.1111/j.1742-4658.2009.07464.x
Keywords
DNA; G-quadruplex; G-quadruplex structure; G-quadruplex topology; G-tetrad; G-tetrad core; grooves in G-quadruplexes; human telomere; loops in G-quadruplexes; RNA
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Funding
- Singapore Biomedical Research Council [07/1/22/19/542]
- Singapore Ministry of Education [ARC30/07, RG62/07]
- Nanyang Technological University [SUG5/06, RG138/06]
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Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This minireview describes the structural diversity or conservation of DNA and RNA human telomeric G-quadruplexes, discusses structural views on targeting these G-quadruplexes and presents some future challenges for structural studies.
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