Journal
FEBS JOURNAL
Volume 276, Issue 9, Pages 2469-2477Publisher
WILEY
DOI: 10.1111/j.1742-4658.2009.06985.x
Keywords
antioxidants; hydrogen peroxide; hydroperoxides; mechanisms; NADPH oxidase; oxidative stress; peroxiredoxins; redox signaling; signal transduction; sulfenic acid
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Funding
- National Institute of General Medical Sciences [RO1 GM50389]
- National Institute of Environmental Health Sciences [P30 ES00210]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES000210] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050389] Funding Source: NIH RePORTER
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Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.
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