Journal
FEBS JOURNAL
Volume 276, Issue 24, Pages 7217-7227Publisher
WILEY
DOI: 10.1111/j.1742-4658.2009.07401.x
Keywords
fusion proteins; paramyxovirus; receptor binding; viral entry
Categories
Funding
- NIAID/NIH [R01AI051517, R21AI074783]
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The paramyxovirus family contains established human pathogens such as the measles virus and human respiratory syncytial virus, as well as emerging pathogens including the Hendra and Nipah viruses and the recently identified human metapneumovirus. Two major envelope glycoproteins, the attachment protein and the fusion protein, promote the processes of viral attachment and virus-cell membrane fusion required for entry. Although common mechanisms of fusion protein proteolytic activation and the mechanism of membrane fusion promotion have been shown in recent years, considerable diversity exists in the family relating to receptor binding and the potential mechanisms of fusion triggering.
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