Journal
FEBS JOURNAL
Volume 276, Issue 19, Pages 5447-5455Publisher
WILEY
DOI: 10.1111/j.1742-4658.2009.07229.x
Keywords
circadian clock; miRNA-192; miRNA-194; Period gene family
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Funding
- Dutch Cancer Society (KWF)
- European Young Investigator Programme
- Centre of Biomedical Genetics (CBG)
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Several biological functions in mammals are regulated in a circadian fashion. The molecular mechanisms orchestrating these circadian rhythms have been unravelled. The biological clock, with its core transcriptional unit Bmal1/CLOCK, is composed of several self-sustaining feedback loops. In this study, we describe another mechanism impinging on the core components of the circadian clock. Using a forward genetic screen, we identified the miR-192/194 cluster as a potent inhibitor of the entire Period gene family. In accordance, the exogenous expression of miR-192/194 leads to an altered circadian rhythm. Thus, our results have uncovered a new mechanism for the control of the circadian clock at the post-transcriptional level.
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