4.6 Review

Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Tumour cell survival signalling by the ERK1/2 pathway

K. Balmanno et al.

CELL DEATH AND DIFFERENTIATION (2009)

Review Biochemistry & Molecular Biology

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

M. Vogler et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Biochemistry & Molecular Biology

βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

Elinor Dehan et al.

MOLECULAR CELL (2009)

Article Genetics & Heredity

BrafV600E cooperates with Pten loss to induce metastatic melanoma

David Dankort et al.

NATURE GENETICS (2009)

Article Oncology

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

Mark S. Cragg et al.

NATURE REVIEWS CANCER (2009)

Review Oncology

Targeting cancer with small molecule kinase inhibitors

Jianming Zhang et al.

NATURE REVIEWS CANCER (2009)

Review Oncology

Oncogene addiction

I. Bernard Weinstein et al.

CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim

Clare Sheridan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

RACK1 and CIS mediate the degradation of BimEL in cancer cells

Weizhou Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Medicine, Research & Experimental

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

Mark S. Cragg et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Biochemistry & Molecular Biology

Multisite phosphorylation regulates Bim stability and apoptotic activity

Anette Hubner et al.

MOLECULAR CELL (2008)

Article Cell Biology

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

Jer-Yen Yang et al.

NATURE CELL BIOLOGY (2008)

Review Cell Biology

The BCL-2 protein family: opposing activities that mediate cell death

Richard J. Youle et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Mutant B-RAF mediates resistance to anoikis via Bad and Bim

K. Boisvert-Adamo et al.

ONCOGENE (2008)

Review Biochemistry & Molecular Biology

FOXOs, cancer and regulation of apoptosis

Z. Fu et al.

ONCOGENE (2008)

Article Oncology

Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survival

Robert A. Cartlidge et al.

PIGMENT CELL & MELANOMA RESEARCH (2008)

Article Cell Biology

c-Cbl is not required for ERK1/2-dependent degradation of BimEL

Ceri M. Wiggins et al.

CELLULAR SIGNALLING (2007)

Article Cell Biology

Bim and the pro-survival bcl-2 proteins - Opposites attract, ERK repels

Katherine E. Ewings et al.

CELL CYCLE (2007)

Article Biochemistry & Molecular Biology

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

Katherine E. Ewings et al.

EMBO JOURNAL (2007)

Review Biochemistry & Molecular Biology

The Bcl-2 apoptotic switch in cancer development and therapy

J. M. Adams et al.

ONCOGENE (2007)

Article Multidisciplinary Sciences

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Simon N. Willis et al.

SCIENCE (2007)

Correction Multidisciplinary Sciences

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (vol 103, pg 14907, 2006)

Junya Kuroda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

Junya Kuroda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

DD Sarbassov et al.

MOLECULAR CELL (2006)

Article Multidisciplinary Sciences

BRAF mutation predicts sensitivity to MEK inhibition

DB Solit et al.

NATURE (2006)

Review Oncology

Promoting apoptosis as a strategy for cancer drug discovery

SW Fesik

NATURE REVIEWS CANCER (2005)

Article Multidisciplinary Sciences

Bim is a suppressor of Myc-induced mouse B cell leukemia

A Egle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Role of Bim in the survival pathway induced by Raf in epithelial cells

M Marani et al.

ONCOGENE (2004)

Article Biochemistry & Molecular Biology

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

JF Ohren et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

R Kuribara et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

Intrinsic tumour suppression

SW Lowe et al.

NATURE (2004)

Article Multidisciplinary Sciences

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

K Lei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML

BJ Druker

ONCOGENE (2002)

Article Biochemistry & Molecular Biology

Novel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571

R Nimmanapalli et al.

ONCOGENE (2002)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)

Review Biochemistry & Molecular Biology

The hallmarks of cancer

D Hanahan et al.